biostudies-literatureUnknown8(1)Santi AIndividual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood reguTranslational psychiatry142https://www.ebi.ac.uk/biostudies/studies/S-EPMC6070549biostudies-literatureCirculating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man.PMC6070549Penninx BWJHBot MAleman AAleman ITSanti AfalseCirculating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man.Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibility, we observed that the anxiogenic effects of either TBI or exposure to life-threatening experiences (predator) were blocked when both stressors were combined. Because TBI increases the entrance into the brain of serum insulin-like growth factor I (IGF-I), a known modulator of anxiety with a wide range of concentrations in the human population, we then determined whether circulating IGF-I is related to anxiety measures. In mice, anxiety-like responses to predator were inversely related to circulating IGF-I levels. Other indicators of mood regu2018-01-01T00:00:00Z2018 Aug2025-04-19T20:57:11.272Z2019-03-26T23:49:59ZS-EPMC60705493006897410.1038/s41398-018-0196-5