{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guillen PO"],"funding":["Marine Institute","Secretaría de Educación Superior, Ciencia, Tecnología e Innovación"],"pagination":["E242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6071026"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(7)"],"pubmed_abstract":["Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation."],"journal":["Marine drugs"],"pubmed_title":["Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation."],"pmcid":["PMC6071026"],"funding_grant_id":["PBA/MB/16/01","PIC-14-CENAIM-001"],"pubmed_authors":["Alonso E","Gegunde S","Thomas OP","Guillen PO","Rodriguez J","Jaramillo KB","Calabro K","Botana LM","Alfonso A"],"additional_accession":[]},"is_claimable":false,"name":"Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation.","description":"Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-26T13:56:09.214Z","creation":"2019-03-26T23:50:26Z"},"accession":"S-EPMC6071026","cross_references":{"pubmed":["30036989"],"doi":["10.3390/md16070242"]}}