{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yaghootkar H"],"funding":["European Research Council","Medical Research Council","National Institute for Health Research (NIHR)","NNF Center for Basic Metabolic Research","Wellcome Trust"],"pagination":["2279-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6071833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(6)"],"pubmed_abstract":["A recent study identified a low-frequency variant at CCND2 associated with lower risk of type 2 diabetes, enhanced insulin response to a glucose challenge, higher height, and, paradoxically, higher BMI. We aimed to replicate the strength and effect size of these associations in independent samples and to assess the underlying mechanism. We genotyped the variant in 29,956 individuals and tested its association with type 2 diabetes and related traits. The low-frequency allele was associated with a lower risk of type 2 diabetes (OR 0.53; P = 2 × 10(-13); 6,647 case vs. 12,645 control subjects), higher disposition index (β = 0.07 log10; P = 2 × 10(-11); n = 13,028), and higher Matsuda index of insulin sensitivity (β = 0.02 log10; P = 5 × 10(-3); n = 13,118) but not fasting proinsulin (β = 0.01"],"journal":["Diabetes"],"pubmed_title":["Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion."],"pmcid":["PMC6071833"],"funding_grant_id":["G0601261","NF-SI-0611-10219","Hansen Group","072960/z/03/z","323195","098395","099177","MC_UU_12013/5","092731","090532","MC_UU_12013/1","085541/Z/08/Z","102215","NF-SI-0611-10099","098381","MC_PC_15018","099177/z12/z"],"pubmed_authors":["McCarthy MI","Ring SM","Yaghootkar H","Thorleifsson G","Stefansson K","Ferrannini E","Steinthorsdottir V","Vangipurapu J","Stancakova A","Morris AD","Wood AR","Frayling TM","Xie W","Walker M","Pedersen O","Guðbjartsson DF","Hansen T","Weedon MN","Lawlor DA","Davey Smith G","Palmer CN","Hattersley AT","Jorgensen T","Freathy RM","Mari A","Laakso M","Thorsteinsdottir U"],"additional_accession":[]},"is_claimable":false,"name":"Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.","description":"A recent study identified a low-frequency variant at CCND2 associated with lower risk of type 2 diabetes, enhanced insulin response to a glucose challenge, higher height, and, paradoxically, higher BMI. We aimed to replicate the strength and effect size of these associations in independent samples and to assess the underlying mechanism. We genotyped the variant in 29,956 individuals and tested its association with type 2 diabetes and related traits. The low-frequency allele was associated with a lower risk of type 2 diabetes (OR 0.53; P = 2 × 10(-13); 6,647 case vs. 12,645 control subjects), higher disposition index (β = 0.07 log10; P = 2 × 10(-11); n = 13,028), and higher Matsuda index of insulin sensitivity (β = 0.02 log10; P = 5 × 10(-3); n = 13,118) but not fasting proinsulin (β = 0.01","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2026-04-07T18:08:31.881Z","creation":"2019-03-26T23:49:12Z"},"accession":"S-EPMC6071833","cross_references":{"pubmed":["25605810"],"doi":["10.2337/db14-1456"]}}