{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(7)"],"submitter":["Singh K"],"funding":["University Grants Commission","Department of Biotechnology, Ministry of Science and Technology"],"pubmed_abstract":["A series of homologous <i>C</i>-nucleoside mimics have been synthesized <i>via</i> an efficient and facile synthetic protocol involving the conjugate addition of purine to sugar derived olefinic ester in good yields. The synthesized compounds were evaluated for their antiplasmodial activity <i>in vitro</i> against both the CQ-sensitive and resistant strains of <i>P. falciparum</i>. Interestingly, all the synthesized nucleoside analogs exhibited an IC<sub>50</sub> of <5 μM, while compounds <b>22a</b>, <b>23a</b>, and <b>23b</b> showed promising antiplasmodial activity with an IC<sub>50</sub> of 1.61, 0.88, and 1.01 μM against the CQ-sensitive <i>Pf</i>3D7 strain and 1.14, 1.01, and 2.57 μM against the CQ-resistant <i>Pf</i>K1 strain, respectively."],"journal":["MedChemComm"],"pagination":["1232-1238"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6071838"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and antiplasmodial activity of purine-based <i>C</i>-nucleoside analogues."],"pmcid":["PMC6071838"],"pubmed_authors":["Shukla SK","Joshi P","Singh K","Tripathi RP","Mahar R","Tripathi R","Baranwal P"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and antiplasmodial activity of purine-based <i>C</i>-nucleoside analogues.","description":"A series of homologous <i>C</i>-nucleoside mimics have been synthesized <i>via</i> an efficient and facile synthetic protocol involving the conjugate addition of purine to sugar derived olefinic ester in good yields. The synthesized compounds were evaluated for their antiplasmodial activity <i>in vitro</i> against both the CQ-sensitive and resistant strains of <i>P. falciparum</i>. Interestingly, all the synthesized nucleoside analogs exhibited an IC<sub>50</sub> of <5 μM, while compounds <b>22a</b>, <b>23a</b>, and <b>23b</b> showed promising antiplasmodial activity with an IC<sub>50</sub> of 1.61, 0.88, and 1.01 μM against the CQ-sensitive <i>Pf</i>3D7 strain and 1.14, 1.01, and 2.57 μM against the CQ-resistant <i>Pf</i>K1 strain, respectively.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-19T20:58:53.556Z","creation":"2019-06-06T23:21:32Z"},"accession":"S-EPMC6071838","cross_references":{"pubmed":["30109012"],"doi":["10.1039/c8md00098k"]}}