{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tyurin AP"],"funding":["Russian Academy of Sciences","National Natural Science Foundation of China","Russian Foundation for Basic Research"],"pagination":["667-675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6071864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["The study of an archived sample of crystallomycin complex using HPLC, ESI HRMS, and 2D NMR showed that two major components of the antibiotic, compounds <b>1</b> and <b>2</b>, are lipopeptides having the same peptide core, Asp1-cyclo(Dab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), <i>N</i>-acylated either with Δ<sup>3</sup>-iso-tetradecenoyl or Δ<sup>3</sup>-anteiso-pentadecenoyl that are identical to aspartocins C and B, respectively. According to the 2D NMR study, compound <b>2</b> in DMSO solution exists as a mixture of four conformers. The producing strain was identified as <i>Streptomyces griseorubens</i>. Compounds <b>1</b> and <b>2</b> have considerable Ca<sup>2+</sup>-dependent activity against Gram-positive bacteria including five MRSA strains."],"journal":["MedChemComm"],"pubmed_title":["Crystallomycin revisited after 60 years: aspartocins B and C."],"pmcid":["PMC6071864"],"funding_grant_id":["81611530716","17-53-53130"],"pubmed_authors":["Grammatikova NE","Efimenko TA","Shuvalov MV","Malanicheva IA","Sun C","Liu S","Shenkarev ZO","Prokhorenko IA","Korshun VA","Tyurin AP","Paramonov AS","Solyev PN","Alferova VA","Efremenkova OV","Terekhova LP"],"additional_accession":[]},"is_claimable":false,"name":"Crystallomycin revisited after 60 years: aspartocins B and C.","description":"The study of an archived sample of crystallomycin complex using HPLC, ESI HRMS, and 2D NMR showed that two major components of the antibiotic, compounds <b>1</b> and <b>2</b>, are lipopeptides having the same peptide core, Asp1-cyclo(Dab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), <i>N</i>-acylated either with Δ<sup>3</sup>-iso-tetradecenoyl or Δ<sup>3</sup>-anteiso-pentadecenoyl that are identical to aspartocins C and B, respectively. According to the 2D NMR study, compound <b>2</b> in DMSO solution exists as a mixture of four conformers. The producing strain was identified as <i>Streptomyces griseorubens</i>. Compounds <b>1</b> and <b>2</b> have considerable Ca<sup>2+</sup>-dependent activity against Gram-positive bacteria including five MRSA strains.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-04-30T23:04:10.382Z","creation":"2019-06-06T19:56:37Z"},"accession":"S-EPMC6071864","cross_references":{"pubmed":["30108957"],"doi":["10.1039/c8md00002f"]}}