{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song J"],"funding":["National Natural Science Foundation of China"],"pagination":["1131-1141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6072089"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(7)"],"pubmed_abstract":["Twenty-four 14-sulfonamide-tetrandrine derivatives as potential anti-cancer agents were synthesized. The synthetic derivatives were investigated for their cytotoxic activity against human cancer cell lines MDA-MB-231, PC3, WM9, HEL and K562. Initially, the IC<sub>50</sub> values (50% inhibitory concentrations) of all of the compounds were determined. These derivatives exhibited potent, but distinct, inhibitory effects on the above-mentioned cell lines. Among them, compound <b>23</b>, which was modified with a 2-naphthalenesulfonyl group at the 14-amino position, showed impressive inhibition of all five cancer cell lines, and especially of MDA-MB-231 cells with an IC<sub>50</sub> value of 1.18 ± 0.14 μM. Further mechanism exploration showed that <b>23</b> induced potent apoptotic cell death on MDA-MB-231 cancer cells in a concentration-dependent manner. The results revealed that <b>23</b> might be a potential anti-cancer drug candidate."],"journal":["MedChemComm"],"pubmed_title":["Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents."],"pmcid":["PMC6072089"],"funding_grant_id":["81472609","81360479"],"pubmed_authors":["Ben-David Y","Pan W","Hu S","Lou H","Zeng X","Chen C","Song J","Lan J","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents.","description":"Twenty-four 14-sulfonamide-tetrandrine derivatives as potential anti-cancer agents were synthesized. The synthetic derivatives were investigated for their cytotoxic activity against human cancer cell lines MDA-MB-231, PC3, WM9, HEL and K562. Initially, the IC<sub>50</sub> values (50% inhibitory concentrations) of all of the compounds were determined. These derivatives exhibited potent, but distinct, inhibitory effects on the above-mentioned cell lines. Among them, compound <b>23</b>, which was modified with a 2-naphthalenesulfonyl group at the 14-amino position, showed impressive inhibition of all five cancer cell lines, and especially of MDA-MB-231 cells with an IC<sub>50</sub> value of 1.18 ± 0.14 μM. Further mechanism exploration showed that <b>23</b> induced potent apoptotic cell death on MDA-MB-231 cancer cells in a concentration-dependent manner. The results revealed that <b>23</b> might be a potential anti-cancer drug candidate.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-19T21:01:04.862Z","creation":"2019-06-06T23:04:02Z"},"accession":"S-EPMC6072089","cross_references":{"pubmed":["30109000"],"doi":["10.1039/c8md00125a"]}}