{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yamamura H"],"funding":["Adaptable and Seamless Technology Transfer Program through Target-Driven R and D","Japan Society for the Promotion of Science"],"pagination":["509-518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6072522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["The emergence of drug-resistant bacteria has led to the high demand for new antibiotics. In this report, we investigated membrane-active antimicrobial β-cyclodextrins. These contain seven amino-modified alkyl groups on a molecule, which act as functional moieties to permeabilize bacterial cell membranes. The polyfunctionalization of cyclodextrins was achieved through a click reaction assisted by microwave irradiation. A survey using derivatives with systematically varied functionalities clarified the unique correlation of the antimicrobial activity of these compounds with their molecular structure and hydrophobicity/hydrophilicity balances. The optimum hydrophobicity for the compounds being membrane-active was specific to bacterial strains and animal cells; this led to specific compounds h"],"journal":["MedChemComm"],"pubmed_title":["Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized <i>via</i> click reactions."],"pmcid":["PMC6072522"],"funding_grant_id":["15K07857","AS2711906T"],"pubmed_authors":["Kato H","Yamamura H","Katsu T","Tomita H","Tanimoto K","Nonaka M","Okuno S","Mitsuhashi R","Masuda K","Miyagawa A"],"additional_accession":[]},"is_claimable":false,"name":"Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized <i>via</i> click reactions.","description":"The emergence of drug-resistant bacteria has led to the high demand for new antibiotics. In this report, we investigated membrane-active antimicrobial β-cyclodextrins. These contain seven amino-modified alkyl groups on a molecule, which act as functional moieties to permeabilize bacterial cell membranes. The polyfunctionalization of cyclodextrins was achieved through a click reaction assisted by microwave irradiation. A survey using derivatives with systematically varied functionalities clarified the unique correlation of the antimicrobial activity of these compounds with their molecular structure and hydrophobicity/hydrophilicity balances. The optimum hydrophobicity for the compounds being membrane-active was specific to bacterial strains and animal cells; this led to specific compounds h","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-05-06T02:57:11.681Z","creation":"2019-03-26T22:50:15Z"},"accession":"S-EPMC6072522","cross_references":{"pubmed":["30108941"],"doi":["10.1039/c7md00592j"]}}