{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Zhao W"],"pubmed_abstract":["<h4>Purpose</h4>To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application.<h4>Materials and methods</h4>RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors.<h4>Results</h4>In the in vitro study, the mean temperature at the front and ventral wall of the spinal canal was 50.8 °C and 43.6 °C, respectively, at 20 mm significantly greater than 37.7 °C and 33.7 ± 1.7 °C, respectively, at 10 mm ablation depth. The coagulative necrosis area was significantly (<i>P</i> < 0.0001) greater at 20 mm depth than at 10 mm depth (mean 17.0 × 20.7 mm<sup>2</sup> vs. 14.2 × 16.6 mm<sup>2</sup>). In the in vivo experiment, the local temperature increased significantly (<i>P</i> < 0.05) from around 36 °C before ablation to over 41 °C at 20 min after ablation, with the temperature at the electrode tip (90.4 °C) and within the vertebral body (67.0 °C) significantly (<i>P</i> < 0.05) greater than at the posterior (41.9 °C) and lateral wall (41.8 °C). From 2 to 5 weeks, bone remodeling began. Clinically, all four patients had successful RFA and vertebroplasty, with no neurological deficits. The pain scores were significanlty (<i>P</i> < 0.05) improved before (4.5-10, mean 8.0) compared with at four weeks (0-1.8, mean 1.8).<h4>Conclusion</h4>The clustered electrode can be efficiently and safely applied in the treatment of spinal tumors without damaging the spinal cord and adjacent nerves by heat distribution."],"journal":["Journal of bone oncology"],"pagination":["69-77"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6072893"],"repository":["biostudies-literature"],"pubmed_title":["Thermal effect of percutaneous radiofrequency ablation with a clustered electrode for vertebral tumors: In vitro and vivo experiments and clinical application."],"pmcid":["PMC6072893"],"pubmed_authors":["Jiang YN","Gao BL","Jin S","Zhao W","Luo G","Peng ZH","Chen JZ","Yi GF","Huang JQ","Wang H","Hu JH"],"additional_accession":[]},"is_claimable":false,"name":"Thermal effect of percutaneous radiofrequency ablation with a clustered electrode for vertebral tumors: In vitro and vivo experiments and clinical application.","description":"<h4>Purpose</h4>To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application.<h4>Materials and methods</h4>RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors.<h4>Results</h4>In the in vitro study, the mean temperature at the front and ventral wall of the spinal canal was 50.8 °C and 43.6 °C, respectively, at 20 mm significantly greater than 37.7 °C and 33.7 ± 1.7 °C, respectively, at 10 mm ablation depth. The coagulative necrosis area was significantly (<i>P</i> < 0.0001) greater at 20 mm depth than at 10 mm depth (mean 17.0 × 20.7 mm<sup>2</sup> vs. 14.2 × 16.6 mm<sup>2</sup>). In the in vivo experiment, the local temperature increased significantly (<i>P</i> < 0.05) from around 36 °C before ablation to over 41 °C at 20 min after ablation, with the temperature at the electrode tip (90.4 °C) and within the vertebral body (67.0 °C) significantly (<i>P</i> < 0.05) greater than at the posterior (41.9 °C) and lateral wall (41.8 °C). From 2 to 5 weeks, bone remodeling began. Clinically, all four patients had successful RFA and vertebroplasty, with no neurological deficits. The pain scores were significanlty (<i>P</i> < 0.05) improved before (4.5-10, mean 8.0) compared with at four weeks (0-1.8, mean 1.8).<h4>Conclusion</h4>The clustered electrode can be efficiently and safely applied in the treatment of spinal tumors without damaging the spinal cord and adjacent nerves by heat distribution.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-26T05:56:17.506Z","creation":"2019-03-26T23:50:47Z"},"accession":"S-EPMC6072893","cross_references":{"pubmed":["30094136"],"doi":["10.1016/j.jbo.2018.07.001"]}}