biostudies-literatureUnknown12Zhao W<h4>Purpose</h4>To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application.<h4>Materials and methods</h4>RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors.<h4>Results</h4>In the in vitro study, the mean temperature at the front and ventral wall of the spinal canal was 50.8 °C and 43.6 °C, respectively, at 20 mm significantly greater than 37.7 °C and 33.7 ± 1.7 °C, respectively, at 10 mm ablation depth. The coagulative necrosis area was significantly (<i>P</i> < 0.0001) greater at 20 mm depth than at 10 mm depth (mean 17.0 × 20.7 mm² vs. 14.2 × 16.6 mm²). In the in vivo experiment, the local temperature increased significantly (<i>P</i> < 0.05) from around 36 °C before ablation to over 41 °C at 20 min after ablation, with the temperature at the electrode tip (90.4 °C) and within the vertebral body (67.0 °C) significantly (<i>P</i> < 0.05) greater than at the posterior (41.9 °C) and lateral wall (41.8 °C). From 2 to 5 weeks, bone remodeling began. Clinically, all four patients had successful RFA and vertebroplasty, with no neurological deficits. The pain scores were significanlty (<i>P</i> < 0.05) improved before (4.5-10, mean 8.0) compared with at four weeks (0-1.8, mean 1.8).<h4>Conclusion</h4>The clustered electrode can be efficiently and safely applied in the treatment of spinal tumors without damaging the spinal cord and adjacent nerves by heat distribution.Journal of bone oncology69-77https://www.ebi.ac.uk/biostudies/studies/S-EPMC6072893biostudies-literatureThermal effect of percutaneous radiofrequency ablation with a clustered electrode for vertebral tumors: In vitro and vivo experiments and clinical application.PMC6072893Jiang YNGao BLJin SZhao WLuo GPeng ZHChen JZYi GFHuang JQWang HHu JHfalseThermal effect of percutaneous radiofrequency ablation with a clustered electrode for vertebral tumors: In vitro and vivo experiments and clinical application.<h4>Purpose</h4>To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application.<h4>Materials and methods</h4>RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors.<h4>Results</h4>In the in vitro study, the mean temperature at the front and ventral wall of the spinal canal was 50.8 °C and 43.6 °C, respectively, at 20 mm significantly greater than 37.7 °C and 33.7 ± 1.7 °C, respectively, at 10 mm ablation depth. The coagulative necrosis area was significantly (<i>P</i> < 0.0001) greater at 20 mm depth than at 10 mm depth (mean 17.0 × 20.7 mm² vs. 14.2 × 16.6 mm²). In the in vivo experiment, the local temperature increased significantly (<i>P</i> < 0.05) from around 36 °C before ablation to over 41 °C at 20 min after ablation, with the temperature at the electrode tip (90.4 °C) and within the vertebral body (67.0 °C) significantly (<i>P</i> < 0.05) greater than at the posterior (41.9 °C) and lateral wall (41.8 °C). From 2 to 5 weeks, bone remodeling began. Clinically, all four patients had successful RFA and vertebroplasty, with no neurological deficits. The pain scores were significanlty (<i>P</i> < 0.05) improved before (4.5-10, mean 8.0) compared with at four weeks (0-1.8, mean 1.8).<h4>Conclusion</h4>The clustered electrode can be efficiently and safely applied in the treatment of spinal tumors without damaging the spinal cord and adjacent nerves by heat distribution.2018-01-01T00:00:00Z2018 Sep2025-04-26T05:56:17.506Z2019-03-26T23:50:47ZS-EPMC60728933009413610.1016/j.jbo.2018.07.001