biostudies-literatureNizampatnam SDOD | ONR | Office of Naval Research GlobalNational Science Foundation (NSF)DOD | ONR | Office of Naval Research Global (ONR Global)National Science Foundation3062https://www.ebi.ac.uk/biostudies/studies/S-EPMC6076288biostudies-literatureUnknown9(1)Sensory stimuli evoke spiking activities patterned across neurons and time that are hypothesized to encode information about their identity. Since the same stimulus can be encountered in a multitude of ways, how stable or flexible are these stimulus-evoked responses? Here we examine this issue in the locust olfactory system. In the antennal lobe, we find that both spatial and temporal features of odor-evoked responses vary in a stimulus-history dependent manner. The response variations are not random, but allow the antennal lobe circuit to enhance the uniqueness of the current stimulus. Nevertheless, information about the odorant identity is conf ounded due to this contrast enhancement computation. Notably, predictions from a linear logical classifier (OR-of-ANDs) that can decode informatiNature communicationsDynamic contrast enhancement and flexible odor codes.PMC6076288N0001416124261453022Saha DChandak RNizampatnam SRaman BfalseDynamic contrast enhancement and flexible odor codes.Sensory stimuli evoke spiking activities patterned across neurons and time that are hypothesized to encode information about their identity. Since the same stimulus can be encountered in a multitude of ways, how stable or flexible are these stimulus-evoked responses? Here we examine this issue in the locust olfactory system. In the antennal lobe, we find that both spatial and temporal features of odor-evoked responses vary in a stimulus-history dependent manner. The response variations are not random, but allow the antennal lobe circuit to enhance the uniqueness of the current stimulus. Nevertheless, information about the odorant identity is conf ounded due to this contrast enhancement computation. Notably, predictions from a linear logical classifier (OR-of-ANDs) that can decode informati2018-01-01T00:00:00Z2018 Aug2026-05-05T22:01:34.414Z2019-03-26T23:52:05ZS-EPMC60762883007630710.1038/s41467-018-05533-6