{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang J"],"funding":["Ministry of Science and Technology of China","Strategic Priority Research Program of the Chinese Academy of Sciences","National Natural Science Foundation of China","Science and Technology Project of Henan Province","Foundation for University Young Key Teacher of Henan Province","Major Science and Technology Project of Henan Province"],"pagination":["187-199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6076378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["Non-small-cell lung cancer (NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here, we employed a sensitive and reliable method to map genome-wide 5hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers fro"],"journal":["Genomics, proteomics & bioinformatics"],"pubmed_title":["5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer."],"pmcid":["PMC6076378"],"funding_grant_id":["XDB14030300","2015GGJS-162","31670895","31430022","31670824","81703598","162102310199","U1504831","161100310100","2016YFC0900300","31400672"],"pubmed_authors":["Li X","Yang YG","Qi Z","Zhang J","Xing Y","Sun B","Tian X","Zhang X","Han X","Liu R","Wang Y","Gao C"],"additional_accession":[]},"is_claimable":false,"name":"5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer.","description":"Non-small-cell lung cancer (NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here, we employed a sensitive and reliable method to map genome-wide 5hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers fro","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2026-05-02T00:28:58.869Z","creation":"2019-03-26T23:50:51Z"},"accession":"S-EPMC6076378","cross_references":{"pubmed":["30010036"],"doi":["10.1016/j.gpb.2018.06.002"]}}