{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim S"],"funding":["NIH HHS","National Science Foundation"],"pagination":["885"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6077975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["The chronic exposure of humans to toxic metals such as cadmium from food and air causes dysfunction of vital organs, neurodegenerative conditions, and cancer. In this regard, members of the ABCB sub-family of the ATP-binding cassette (ABC) transporter superfamily, ABCB6/HMT-1, are acutely required for the detoxification of heavy metals and are present in genomes of many organisms including the nematode worm, <i>Caenorhabditis elegans</i> and humans. We showed previously that <i>C. elegans</i> ABCB6/HMT-1 detoxifies cadmium, copper, and arsenic, and is expressed in liver-like cells, the coelomocytes, head neurons and intestinal cells, which are the cell types that are affected by heavy metal poisoning in humans. The subcellular localization of ABCB6/HMT-1 proteins is unclear. ABCB6/HMT-1 pr"],"journal":["Frontiers in physiology"],"pubmed_title":["N-Terminal Extension and C-Terminal Domains Are Required for ABCB6/HMT-1 Protein Interactions, Function in Cadmium Detoxification, and Localization to the Endosomal-Recycling System in <i>Caenorhabditis elegans</i>."],"pmcid":["PMC6077975"],"funding_grant_id":["NSF-MCB-0923731","P40 OD010440"],"pubmed_authors":["Kim S","Vatamaniuk OK","Sharma AK"],"additional_accession":[]},"is_claimable":false,"name":"N-Terminal Extension and C-Terminal Domains Are Required for ABCB6/HMT-1 Protein Interactions, Function in Cadmium Detoxification, and Localization to the Endosomal-Recycling System in <i>Caenorhabditis elegans</i>.","description":"The chronic exposure of humans to toxic metals such as cadmium from food and air causes dysfunction of vital organs, neurodegenerative conditions, and cancer. In this regard, members of the ABCB sub-family of the ATP-binding cassette (ABC) transporter superfamily, ABCB6/HMT-1, are acutely required for the detoxification of heavy metals and are present in genomes of many organisms including the nematode worm, <i>Caenorhabditis elegans</i> and humans. We showed previously that <i>C. elegans</i> ABCB6/HMT-1 detoxifies cadmium, copper, and arsenic, and is expressed in liver-like cells, the coelomocytes, head neurons and intestinal cells, which are the cell types that are affected by heavy metal poisoning in humans. The subcellular localization of ABCB6/HMT-1 proteins is unclear. ABCB6/HMT-1 pr","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-18T14:35:57.284Z","creation":"2019-03-26T23:51:16Z"},"accession":"S-EPMC6077975","cross_references":{"pubmed":["30104978"],"doi":["10.3389/fphys.2018.00885"]}}