{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(7)"],"submitter":["Jin Y"],"pubmed_abstract":["Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3-only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and antiapoptotic proteins. Although the detailed mech"],"journal":["Molecules and cells"],"pagination":["684-694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6078858"],"repository":["biostudies-literature"],"pubmed_title":["Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members."],"pmcid":["PMC6078858"],"pubmed_authors":["You L","Kim HJ","Jin Y","Lee HW"],"additional_accession":[]},"is_claimable":false,"name":"Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members.","description":"Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3-only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and antiapoptotic proteins. Although the detailed mech","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-04T23:44:41.112Z","creation":"2019-03-26T23:52:12Z"},"accession":"S-EPMC6078858","cross_references":{"pubmed":["29937479"],"doi":["10.14348/molcells.2018.0206"]}}