{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Nagpal N"],"pubmed_abstract":["Mediator complex has been extensively shown to regulate the levels of several protein-coding genes; however, its role in the regulation of miRNAs in humans remains unstudied so far. Here we show that MED1, a Mediator subunit in the Middle module of Mediator complex, is overexpressed in breast cancer and is a negative prognostic factor. The levels of several miRNAs (miR-100-5p, -191-5p, -193b-3p, -205-5p, -326, -422a and -425-5p) were found to be regulated by MED1. MED1 induces miR-191/425 cluster in an estrogen receptor-alpha (ER-α) dependent manner. Occupancy of MED1 on estrogen response elements (EREs) upstream of miR-191/425 cluster is estrogen and ER-α-dependent and ER-α-induced expression of these miRNAs is MED1-dependent. MED1 mediates induction of cell proliferation and migration an"],"journal":["Scientific reports"],"pagination":["11805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6081450"],"repository":["biostudies-literature"],"pubmed_title":["Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer."],"pmcid":["PMC6081450"],"pubmed_authors":["Thakur JK","Durante G","Sharma S","Nagpal N","Ferracin M","Kulshreshtha R","Maji S"],"additional_accession":[]},"is_claimable":false,"name":"Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer.","description":"Mediator complex has been extensively shown to regulate the levels of several protein-coding genes; however, its role in the regulation of miRNAs in humans remains unstudied so far. Here we show that MED1, a Mediator subunit in the Middle module of Mediator complex, is overexpressed in breast cancer and is a negative prognostic factor. The levels of several miRNAs (miR-100-5p, -191-5p, -193b-3p, -205-5p, -326, -422a and -425-5p) were found to be regulated by MED1. MED1 induces miR-191/425 cluster in an estrogen receptor-alpha (ER-α) dependent manner. Occupancy of MED1 on estrogen response elements (EREs) upstream of miR-191/425 cluster is estrogen and ER-α-dependent and ER-α-induced expression of these miRNAs is MED1-dependent. MED1 mediates induction of cell proliferation and migration an","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-03T22:14:07.085Z","creation":"2019-03-26T23:50:56Z"},"accession":"S-EPMC6081450","cross_references":{"pubmed":["30087366"],"doi":["10.1038/s41598-018-29546-9"]}}