{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(2)"],"submitter":["Wang Z"],"funding":["Construct Program of the Key Discipline in Hunan province"],"pubmed_abstract":["A series of 3',4',5'-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized. The potential activity of these compounds as anti-tumor agents was evaluated by cytotoxicity assay in MGC-803 (human gastric cancer), MCF-7 (human breast cancer), HepG-2 (human hepatoma) and MFC (mouse gastric cancer) tumor cell lines. Among them, compound <b>15</b> 7-(3-(2-chloro-1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)propoxy)-2-(3,4,5-trimethoxyphenyl)-4<i>H</i>-chromen-4-one displayed the most potent antiproliferative activity, with IC<sub>50</sub> values of 20.47 ± 2.07, 43.42 ± 3.56, 35.45 ± 2.03 μM and 23.47 ± 3.59 μM, respectively. The flow cytometry (FCM) results showed that compound <b>15</b> caused the cell cycle to be arrested in G1 phase and induce"],"journal":["MedChemComm"],"pagination":["305-315"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6083785"],"repository":["biostudies-literature"],"pubmed_title":["Design, synthesis and biological evaluation of 3',4',5'-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents."],"pmcid":["PMC6083785"],"pubmed_authors":["Liu J","Zheng X","Cao X","Lei X","Xiong R","Xiong S","Chen Y","Tang G","Wang Z","Deng X"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis and biological evaluation of 3',4',5'-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents.","description":"A series of 3',4',5'-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized. The potential activity of these compounds as anti-tumor agents was evaluated by cytotoxicity assay in MGC-803 (human gastric cancer), MCF-7 (human breast cancer), HepG-2 (human hepatoma) and MFC (mouse gastric cancer) tumor cell lines. Among them, compound <b>15</b> 7-(3-(2-chloro-1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)propoxy)-2-(3,4,5-trimethoxyphenyl)-4<i>H</i>-chromen-4-one displayed the most potent antiproliferative activity, with IC<sub>50</sub> values of 20.47 ± 2.07, 43.42 ± 3.56, 35.45 ± 2.03 μM and 23.47 ± 3.59 μM, respectively. The flow cytometry (FCM) results showed that compound <b>15</b> caused the cell cycle to be arrested in G1 phase and induce","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-04T09:45:58.721Z","creation":"2019-03-27T00:13:42Z"},"accession":"S-EPMC6083785","cross_references":{"pubmed":["30108924"],"doi":["10.1039/c7md00578d"]}}