biostudies-literatureUnknown9(2)Wang ZConstruct Program of the Key Discipline in Hunan provinceA series of 3',4',5'-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized. The potential activity of these compounds as anti-tumor agents was evaluated by cytotoxicity assay in MGC-803 (human gastric cancer), MCF-7 (human breast cancer), HepG-2 (human hepatoma) and MFC (mouse gastric cancer) tumor cell lines. Among them, compound <b>15</b> 7-(3-(2-chloro-1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)propoxy)-2-(3,4,5-trimethoxyphenyl)-4<i>H</i>-chromen-4-one displayed the most potent antiproliferative activity, with IC₅₀ values of 20.47 ± 2.07, 43.42 ± 3.56, 35.45 ± 2.03 μM and 23.47 ± 3.59 μM, respectively. The flow cytometry (FCM) results showed that compound <b>15</b> caused the cell cycle to be arrested in G1 phase and induceMedChemComm305-315https://www.ebi.ac.uk/biostudies/studies/S-EPMC6083785biostudies-literatureDesign, synthesis and biological evaluation of 3',4',5'-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents.PMC6083785Liu JZheng XCao XLei XXiong RXiong SChen YTang GWang ZDeng XfalseDesign, synthesis and biological evaluation of 3',4',5'-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents.A series of 3',4',5'-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized. The potential activity of these compounds as anti-tumor agents was evaluated by cytotoxicity assay in MGC-803 (human gastric cancer), MCF-7 (human breast cancer), HepG-2 (human hepatoma) and MFC (mouse gastric cancer) tumor cell lines. Among them, compound <b>15</b> 7-(3-(2-chloro-1<i>H</i>-benzo[<i>d</i>]imidazol-1-yl)propoxy)-2-(3,4,5-trimethoxyphenyl)-4<i>H</i>-chromen-4-one displayed the most potent antiproliferative activity, with IC₅₀ values of 20.47 ± 2.07, 43.42 ± 3.56, 35.45 ± 2.03 μM and 23.47 ± 3.59 μM, respectively. The flow cytometry (FCM) results showed that compound <b>15</b> caused the cell cycle to be arrested in G1 phase and induce2018-01-01T00:00:00Z2018 Feb2025-04-04T09:45:58.721Z2019-03-27T00:13:42ZS-EPMC60837853010892410.1039/c7md00578d