{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35(8)"],"submitter":["Cordeiro FB"],"pubmed_abstract":["Purpose
The decline in female fecundity with age may be caused by decreased oocyte quality, a factor that may be associated with the altered composition of follicular fluid (FF).Methods
In an effort to better understand follicular aging and the role of lipids in a given biological system, we present a prospective study that compares lipid profiles of FF from women older than 35 years (aging group, n = 12) to women equal or younger than 35 years old (control group, n = 17). FF lipids were extracted, and mass spectra were generated using a Waters Synapt G1 Q-TOF in MS mode. MS data was evaluated for both multi- and univariate statistics. The lipids identified as potential biomarkers of follicle aging were attributed by the online databases Lipid Maps, followed by pathway netw"],"journal":["Journal of assisted reproduction and genetics"],"pagination":["1385-1393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6086795"],"repository":["biostudies-literature"],"pubmed_title":["Ovarian environment aging: follicular fluid lipidomic and related metabolic pathways."],"pmcid":["PMC6086795"],"pubmed_authors":["Cordeiro FB","Montani DA","Fraietta R","Gozzo FC","Turco EGL","Pilau EJ"],"additional_accession":[]},"is_claimable":false,"name":"Ovarian environment aging: follicular fluid lipidomic and related metabolic pathways.","description":"Purpose
The decline in female fecundity with age may be caused by decreased oocyte quality, a factor that may be associated with the altered composition of follicular fluid (FF).Methods
In an effort to better understand follicular aging and the role of lipids in a given biological system, we present a prospective study that compares lipid profiles of FF from women older than 35 years (aging group, n = 12) to women equal or younger than 35 years old (control group, n = 17). FF lipids were extracted, and mass spectra were generated using a Waters Synapt G1 Q-TOF in MS mode. MS data was evaluated for both multi- and univariate statistics. The lipids identified as potential biomarkers of follicle aging were attributed by the online databases Lipid Maps, followed by pathway netw","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-04T08:44:05.317Z","creation":"2019-08-07T07:02:09Z"},"accession":"S-EPMC6086795","cross_references":{"pubmed":["30014448"],"doi":["10.1007/s10815-018-1259-5"]}}