biostudies-literatureUnknown35(8)Cordeiro FB<h4>Purpose</h4>The decline in female fecundity with age may be caused by decreased oocyte quality, a factor that may be associated with the altered composition of follicular fluid (FF).<h4>Methods</h4>In an effort to better understand follicular aging and the role of lipids in a given biological system, we present a prospective study that compares lipid profiles of FF from women older than 35 years (aging group, n = 12) to women equal or younger than 35 years old (control group, n = 17). FF lipids were extracted, and mass spectra were generated using a Waters Synapt G1 Q-TOF in MS mode. MS data was evaluated for both multi- and univariate statistics. The lipids identified as potential biomarkers of follicle aging were attributed by the online databases Lipid Maps, followed by pathway netwJournal of assisted reproduction and genetics1385-1393https://www.ebi.ac.uk/biostudies/studies/S-EPMC6086795biostudies-literatureOvarian environment aging: follicular fluid lipidomic and related metabolic pathways.PMC6086795Cordeiro FBMontani DAFraietta RGozzo FCTurco EGLPilau EJfalseOvarian environment aging: follicular fluid lipidomic and related metabolic pathways.<h4>Purpose</h4>The decline in female fecundity with age may be caused by decreased oocyte quality, a factor that may be associated with the altered composition of follicular fluid (FF).<h4>Methods</h4>In an effort to better understand follicular aging and the role of lipids in a given biological system, we present a prospective study that compares lipid profiles of FF from women older than 35 years (aging group, n = 12) to women equal or younger than 35 years old (control group, n = 17). FF lipids were extracted, and mass spectra were generated using a Waters Synapt G1 Q-TOF in MS mode. MS data was evaluated for both multi- and univariate statistics. The lipids identified as potential biomarkers of follicle aging were attributed by the online databases Lipid Maps, followed by pathway netw2018-01-01T00:00:00Z2018 Aug2025-04-04T08:44:05.317Z2019-08-07T07:02:09ZS-EPMC60867953001444810.1007/s10815-018-1259-5