biostudies-literatureBompas ELigue de L&apos;Ain contre le Cancer, LYricla Fondation ARC, Infosarcome, InterSARC (INCA), LabEx DEvweCANRREPS (INCA)NetSARC (INCA)Association DAM&apos;s, Ensemble contre Le GIST, Eurosarc4023-4035https://www.ebi.ac.uk/biostudies/studies/S-EPMC6089183biostudies-literatureUnknown7(8)Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database. A descriptive analysis of patients' characteristics and prognostic factors was conducted on both series which were compared. In the retrospective series, histological subtypes were embryonal (E-RMS) for 21% of patients, alveolar (A-RMS) for 35% of patients, andCancer medicineOutcome of 449 adult patients with rhabdomyosarcoma: an observational ambispective nationwide study.PMC6089183ANR-10-LABX-0061FP7-278742DGOS-INCa-4664Piperno-Neumann SSoulie PChevreau CIsambert NRios MKaranian MPenel NMir ODuffaud FItaliano ARay-Coquard ICampion LSaada-Bouzid ELe Cesne ADelcambre CBlay JYKurtz JEDubray-Longeras PLe Loarer FBompas EToulmonde MfalseOutcome of 449 adult patients with rhabdomyosarcoma: an observational ambispective nationwide study.Five-year overall survival (OS) of localized RMS exceeds 70% in children (<18) but is very poor in adult patients. We analyzed the outcome and prognostic factors (PF) of a national series of adult patients with RMS in a large study. The study population consisted of two different cohorts: a retrospective cohort (157 adult patients treated in 13 reference centers between 05/1981 and 02/2010) and the prospective cohort (292 patients with RMS diagnosed and treated between 01/2010 and 12/2014 in France) included in the NetSarc database. A descriptive analysis of patients' characteristics and prognostic factors was conducted on both series which were compared. In the retrospective series, histological subtypes were embryonal (E-RMS) for 21% of patients, alveolar (A-RMS) for 35% of patients, and2018-01-01T00:00:00Z2018 Aug2025-04-21T14:52:54.527Z2019-03-26T23:51:38ZS-EPMC60891832995649310.1002/cam4.1374