biostudies-literatureJoo JINIGMS NIH HHS12077https://www.ebi.ac.uk/biostudies/studies/S-EPMC6089891biostudies-literatureUnknown8(1)Cell state transition is at the core of biological processes in metazoan, which includes cell differentiation, epithelial-to-mesenchymal transition (EMT) and cell reprogramming. In these cases, it is important to understand the molecular mechanism of cellular stability and how the transitions happen between different cell states, which is controlled by a gene regulatory network (GRN) hard-wired in the genome. Here we use Boolean modeling of GRN to study the cell state transition of EMT and systematically compare four available methods to calculate the cellular stability of three cell states in EMT in both normal and genetically mutated cases. The results produced from four methods generally agree but do not totally agree with each other. We show that distribution of one-degree neighborhoodScientific reportsDetermining Relative Dynamic Stability of Cell States Using Boolean Network Model.PMC6089891R01 GM109964P50 GM076547Joo JIZhou JXHuang SCho KHfalseDetermining Relative Dynamic Stability of Cell States Using Boolean Network Model.Cell state transition is at the core of biological processes in metazoan, which includes cell differentiation, epithelial-to-mesenchymal transition (EMT) and cell reprogramming. In these cases, it is important to understand the molecular mechanism of cellular stability and how the transitions happen between different cell states, which is controlled by a gene regulatory network (GRN) hard-wired in the genome. Here we use Boolean modeling of GRN to study the cell state transition of EMT and systematically compare four available methods to calculate the cellular stability of three cell states in EMT in both normal and genetically mutated cases. The results produced from four methods generally agree but do not totally agree with each other. We show that distribution of one-degree neighborhood2018-01-01T00:00:00Z2018 Aug2025-04-21T15:00:11.099Z2019-03-26T23:51:38ZS-EPMC60898913010457210.1038/s41598-018-30544-0