{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferlazzo ML"],"funding":["Commissariat Général à l'Investissement","Fibermetrix Company","Centre National d’Etudes Spatiales"],"pagination":["21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6092269"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2"],"pubmed_abstract":["Iodine-containing contrast media (ICM) are extensively used to improve image quality and information content in x-ray-based examinations, particularly in computed tomography (CT). In parallel, there is increasing evidence that the use of ICM during CT sessions is associated with deoxyribonucleic acid (DNA) breaks that may influence the estimation of the risks linked to x-ray exposure. Why has iodine been preferred to any other heavy elements to enhance contrast in radiodiagnostics? How to understand such DNA breaks effect? We searched for the answers in the early times of x-ray medical use. It appeared that the maximal ratio between the relative iodine and water mass energy absorption coefficients is reached in the range of 40-60 keV, which defines the energy range in which the dose is pre"],"journal":["European radiology experimental"],"pubmed_title":["DNA breaks induced by iodine-containing contrast medium in radiodiagnostics: a problem of tungsten?"],"pmcid":["PMC6092269"],"funding_grant_id":["Post-doctoral fellowship","INDIRA Project","PhD grant"],"pubmed_authors":["Biston MC","Devic C","Charvet AM","Joubert A","Colin C","Ferlazzo ML","Pilleul F","Bourguignon M","Foray N","Granzotto A"],"additional_accession":[]},"is_claimable":false,"name":"DNA breaks induced by iodine-containing contrast medium in radiodiagnostics: a problem of tungsten?","description":"Iodine-containing contrast media (ICM) are extensively used to improve image quality and information content in x-ray-based examinations, particularly in computed tomography (CT). In parallel, there is increasing evidence that the use of ICM during CT sessions is associated with deoxyribonucleic acid (DNA) breaks that may influence the estimation of the risks linked to x-ray exposure. Why has iodine been preferred to any other heavy elements to enhance contrast in radiodiagnostics? How to understand such DNA breaks effect? We searched for the answers in the early times of x-ray medical use. It appeared that the maximal ratio between the relative iodine and water mass energy absorption coefficients is reached in the range of 40-60 keV, which defines the energy range in which the dose is pre","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-22T14:10:35.136Z","creation":"2019-03-26T23:52:47Z"},"accession":"S-EPMC6092269","cross_references":{"pubmed":["30148253"],"doi":["10.1186/s41747-018-0050-9"]}}