{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Spejo AB"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["230"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6092804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors to lesioned neurons.<h4>Methods</h4>Lewis adult female rats were submitted to a unilateral ventral funiculus cut at the spinal levels L4, L5, and L6. The animals were divided into the following groups: IA (intramedullary axotomy), IA + DMEM (Dulbecco's modified Eagle's medium), IA + FS (fibrin sealant), IA + MSC (10<sup>6</sup> cells), and IA + FS + MSC (10<sup>6</sup> cells). Seven days after injury, qPCR (n = 5) was performed to assess gene expression of VEGF, BDNF, iNOS2, arginase-1, TNF-α, I"],"journal":["Journal of neuroinflammation"],"pubmed_title":["Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells."],"pmcid":["PMC6092804"],"funding_grant_id":["303085/2017-7","2014/06892-3","300553/2013-9","2013/16168-8","2012/22750-9"],"pubmed_authors":["Gomes DA","Chiarotto GB","Barraviera B","Ferreira RS","Spejo AB","Ferreira ADF","Oliveira ALR"],"additional_accession":[]},"is_claimable":false,"name":"Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells.","description":"<h4>Background</h4>Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors to lesioned neurons.<h4>Methods</h4>Lewis adult female rats were submitted to a unilateral ventral funiculus cut at the spinal levels L4, L5, and L6. The animals were divided into the following groups: IA (intramedullary axotomy), IA + DMEM (Dulbecco's modified Eagle's medium), IA + FS (fibrin sealant), IA + MSC (10<sup>6</sup> cells), and IA + FS + MSC (10<sup>6</sup> cells). Seven days after injury, qPCR (n = 5) was performed to assess gene expression of VEGF, BDNF, iNOS2, arginase-1, TNF-α, I","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-19T10:56:58.101Z","creation":"2019-03-26T23:51:43Z"},"accession":"S-EPMC6092804","cross_references":{"pubmed":["30107848"],"doi":["10.1186/s12974-018-1268-4"]}}