{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muzny CA"],"funding":["National Institute of Allergy and Infectious Diseases","Louisiana Biomedical Research Network","NCATS NIH HHS","NIAID NIH HHS","University of Alabama-Birmingham Center for Clinical and Translational Science","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["966-978"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6093354"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["218(6)"],"pubmed_abstract":["<h4>Background</h4>The sequence of events preceding incident bacterial vaginosis (iBV) is unclear.<h4>Methods</h4>African American women who have sex with women, who had no Amsel criteria and Nugent scores of 0-3, were followed for 90 days to detect iBV (defined as a Nugent score of 7-10 on at least 2-3 consecutive days), using self-collected vaginal swab specimens. For women with iBV (cases) and women maintaining normal vaginal flora (healthy women), 16S ribosomal RNA gene sequencing targeting V4 was performed. Longitudinal vaginal microbiome data were analyzed.<h4>Results</h4>Of 204 women screened, 42 enrolled; of these, 45% developed iBV. Sequencing was performed on 448 specimens from 14 cases and 8 healthy women. Among healthy women, Lactobacillus crispatus dominated the vaginal microb"],"journal":["The Journal of infectious diseases"],"pubmed_title":["Identification of Key Bacteria Involved in the Induction of Incident Bacterial Vaginosis: A Prospective Study."],"pmcid":["PMC6093354"],"funding_grant_id":["K23AI106957","P20 GM103424","K23 AI106957","P20GM103424","UL1TR001417","UL1 TR001417","U19 AI113212"],"pubmed_authors":["Welsh DA","Van Der Pol WJ","Redden DT","Muzny CA","Talluri R","Aaron KJ","Blanchard E","Taylor CM","Martin DH","Luo M","Lefkowitz EJ","Griswold ME","Schwebke JR"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Key Bacteria Involved in the Induction of Incident Bacterial Vaginosis: A Prospective Study.","description":"<h4>Background</h4>The sequence of events preceding incident bacterial vaginosis (iBV) is unclear.<h4>Methods</h4>African American women who have sex with women, who had no Amsel criteria and Nugent scores of 0-3, were followed for 90 days to detect iBV (defined as a Nugent score of 7-10 on at least 2-3 consecutive days), using self-collected vaginal swab specimens. For women with iBV (cases) and women maintaining normal vaginal flora (healthy women), 16S ribosomal RNA gene sequencing targeting V4 was performed. Longitudinal vaginal microbiome data were analyzed.<h4>Results</h4>Of 204 women screened, 42 enrolled; of these, 45% developed iBV. Sequencing was performed on 448 specimens from 14 cases and 8 healthy women. Among healthy women, Lactobacillus crispatus dominated the vaginal microb","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2026-04-29T02:47:40.421Z","creation":"2019-08-20T07:00:31Z"},"accession":"S-EPMC6093354","cross_references":{"pubmed":["29718358"],"doi":["10.1093/infdis/jiy243"]}}