biostudies-literatureUnknown5(8)Hermann BIn this case study, we report the longitudinal and multimodal follow-up of a catastrophic initial presentation of cerebral fat embolism syndrome. We show that despite the initial severity, the cognitive outcome was ultimately very good but with a highly nonlinear time-course and prolonged loss of consciousness (more than 2 months). Repeated clinical assessments and brain-imaging techniques (electroencephalography, event-related potential, ¹⁸-Fluoro-Deoxy-Glucose-PET and magnetic resonance imaging) allowed us to monitor and anticipate this dynamic, providing relevant information to guide decision making in front of withdrawal of life-sustaining therapy discussions. This case illustrates the value of multimodal functional imaging in devastating brain injuries.Annals of clinical and translational neurology988-995https://www.ebi.ac.uk/biostudies/studies/S-EPMC6093841biostudies-literatureUnexpected good outcome in severe cerebral fat embolism syndrome.PMC6093841Stender JPaquereau JMonsel ARobert HPyatigorskaya NLangeron ONaccache LHermann BHabert MOBrisson HfalseUnexpected good outcome in severe cerebral fat embolism syndrome.In this case study, we report the longitudinal and multimodal follow-up of a catastrophic initial presentation of cerebral fat embolism syndrome. We show that despite the initial severity, the cognitive outcome was ultimately very good but with a highly nonlinear time-course and prolonged loss of consciousness (more than 2 months). Repeated clinical assessments and brain-imaging techniques (electroencephalography, event-related potential, ¹⁸-Fluoro-Deoxy-Glucose-PET and magnetic resonance imaging) allowed us to monitor and anticipate this dynamic, providing relevant information to guide decision making in front of withdrawal of life-sustaining therapy discussions. This case illustrates the value of multimodal functional imaging in devastating brain injuries.2018-01-01T00:00:00Z2018 Aug2025-04-19T10:57:43.01Z2019-03-26T23:52:07ZS-EPMC60938413012832410.1002/acn3.596