biostudies-literatureComes ALNovo NordiskDeutsche Forschungsgemeinschaft (German Research Foundation)National Alliance for Research on Schizophrenia and Depression (NARSAD)EC | Horizon 2020 (European Union Framework Programme for Research and Innovation)Novo Nordisk Foundation Center for Protein ResearchNovo Nordisk Fonden160https://www.ebi.ac.uk/biostudies/studies/S-EPMC6095863biostudies-literatureUnknown8(1)Recent improvements in high-throughput proteomic approaches are likely to constitute an essential advance in biomarker discovery, holding promise for improved personalized care and drug development. These methodologies have been applied to study multivariate protein patterns and provide valuable data of peripheral tissues. To highlight findings of the last decade for three of the most common psychiatric disorders, namely schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD), we queried PubMed. Here we delve into the findings from thirty studies, which used proteomics and multiplex immunoassay approaches for peripheral blood biomarker exploration. In an explorative approach, we ran enrichment analyses in peripheral blood according to these results and ascertained thTranslational psychiatryProteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future.PMC6095863SCHU 1603/4-1, 5-1, 7-1NNF15SA0018240MU 3525/3-1686547; MSmed project25015PI Matthias MannNNF15CC0001Schulze TGComes ALGeyer PEPapiol SMann MMueller TfalseProteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future.Recent improvements in high-throughput proteomic approaches are likely to constitute an essential advance in biomarker discovery, holding promise for improved personalized care and drug development. These methodologies have been applied to study multivariate protein patterns and provide valuable data of peripheral tissues. To highlight findings of the last decade for three of the most common psychiatric disorders, namely schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD), we queried PubMed. Here we delve into the findings from thirty studies, which used proteomics and multiplex immunoassay approaches for peripheral blood biomarker exploration. In an explorative approach, we ran enrichment analyses in peripheral blood according to these results and ascertained th2018-01-01T00:00:00Z2018 Aug2025-04-21T17:42:46.165Z2019-03-26T23:51:46ZS-EPMC60958633011592610.1038/s41398-018-0219-2