biostudies-literatureSimon MJNIA NIH HHSNINDS NIH HHS12389https://www.ebi.ac.uk/biostudies/studies/S-EPMC6098119biostudies-literatureUnknown8(1)The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementiaScientific reportsTranscriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology.PMC6098119P30 AG008017R01 AG054456F31 AG054093R01 NS089709Boespflug ELIliff JJSimon MJWang MXWoltjer RLRoese NEMurchison CFfalseTranscriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology.The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementia2018-01-01T00:00:00Z2018 Aug2026-05-04T05:29:54.787Z2025-06-01T03:57:31.442ZS-EPMC60981193012029910.1038/s41598-018-30779-x