biostudies-literatureLeibing TDeutsche Forschungsgemeinschaft707-722https://www.ebi.ac.uk/biostudies/studies/S-EPMC6099291biostudies-literatureUnknown68(2)Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult liver size and metabolic liver zonation. The cellular origin of Wnt ligands responsible for homeostatic liver/body weight ratio (LW/BW) remained unclear, which was also attributable to a lack of suitable endothelial Cre driver mice. To comprehensively analyze the effects of hepatic angiocrine Wnt signaling on liver development and metabolic functions, we used endothelial subtype-specific Stab2-Cre driver mice to delete Wls from hepatic endothelial cells (HECs). The resultant Stab2-Cre^tg/wt ;Wls^fl/fl (Wls-HECKO) mice were viable, but showed a significantlHepatology (Baltimore, Md.)Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.PMC6099291DFG INST 91027/10-1 FUGGGRK2099/RTG2099, project 7DFG INST 91027/9-1 FUGGSFB-TR23, project B1Geraud CZierow JLeibing TSchledzewski KOkun JGGoerdt SOlsavszky VAugustin HGKoch PSBoutros MWohlfeil SAAugustin ILanghans CDfalseAngiocrine Wnt signaling controls liver growth and metabolic maturation in mice.Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult liver size and metabolic liver zonation. The cellular origin of Wnt ligands responsible for homeostatic liver/body weight ratio (LW/BW) remained unclear, which was also attributable to a lack of suitable endothelial Cre driver mice. To comprehensively analyze the effects of hepatic angiocrine Wnt signaling on liver development and metabolic functions, we used endothelial subtype-specific Stab2-Cre driver mice to delete Wls from hepatic endothelial cells (HECs). The resultant Stab2-Cre^tg/wt ;Wls^fl/fl (Wls-HECKO) mice were viable, but showed a significantl2018-01-01T00:00:00Z2018 Aug2026-05-05T20:38:03.99Z2019-03-26T23:52:24ZS-EPMC60992912905945510.1002/hep.29613