{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(7)"],"submitter":["Tan J"],"pubmed_abstract":["Blood stasis syndrome (BSS) is one of the most common Chinese medicine patterns in coronary heart disease. Our previous work proved that Xueshuan Xinmaining Tablet (XXT) could treat blood stasis through regulating the expression of F13a1, Car1 and Tbxa2r. In the current study, the effect and mechanism of XXT on BSS was comprehensively and holistically investigated based on a metabolomics approach. Urine and plasma samples of 10 BBS rats treated with XXT (XT), 9 BSS model rats (BM) and 11 normal control (NC) rats were collected and then determined by UPLC-Q/TOP-MS. Multivariate analyses were applied to distinguish differentiate urinary and plasma metabolite patterns between three groups. Results showed that a clear separation of three groups was achieved. XT group was located between BM gro"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E1650"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6099806"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive Metabolomics Analysis of Xueshuan Xinmaining Tablet in Blood Stasis Model Rats Using UPLC-Q/TOF-MS."],"pmcid":["PMC6099806"],"pubmed_authors":["Liu J","Xiong L","Tan J","Wang C","Zhou B","Wang F","Li P","Zhu H"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive Metabolomics Analysis of Xueshuan Xinmaining Tablet in Blood Stasis Model Rats Using UPLC-Q/TOF-MS.","description":"Blood stasis syndrome (BSS) is one of the most common Chinese medicine patterns in coronary heart disease. Our previous work proved that Xueshuan Xinmaining Tablet (XXT) could treat blood stasis through regulating the expression of F13a1, Car1 and Tbxa2r. In the current study, the effect and mechanism of XXT on BSS was comprehensively and holistically investigated based on a metabolomics approach. Urine and plasma samples of 10 BBS rats treated with XXT (XT), 9 BSS model rats (BM) and 11 normal control (NC) rats were collected and then determined by UPLC-Q/TOP-MS. Multivariate analyses were applied to distinguish differentiate urinary and plasma metabolite patterns between three groups. Results showed that a clear separation of three groups was achieved. XT group was located between BM gro","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-05-18T12:18:28.341Z","creation":"2025-05-18T12:18:28.341Z"},"accession":"S-EPMC6099806","cross_references":{"pubmed":["29986394"],"doi":["10.3390/molecules23071650"]}}