biostudies-literatureUnknown115(33)Kim HThe circadian clock coordinates the daily cyclic rhythm of numerous biological processes by regulating a large portion of the transcriptome. In animals, the circadian clock is involved in aging and senescence, and circadian disruption by mutations in clock genes frequently accelerates aging. Conversely, aging alters circadian rhythmicity, which causes age-associated physiological alterations. However, interactions between the circadian clock and aging have been rarely studied in plants. Here, we investigated potential roles for the circadian clock in the regulation of leaf senescence in plants. Members of the evening complex in <i>Arabidopsis</i> circadian clock, EARLY FLOWERING 3 (ELF3), EARLY FLOWERING 4 (ELF4), and LUX ARRHYTHMO (LUX), as well as the morning component PSEUDO-RESPONSE REProceedings of the National Academy of Sciences of the United States of America8448-8453https://www.ebi.ac.uk/biostudies/studies/S-EPMC6099856biostudies-literatureCircadian control of <i>ORE1</i> by PRR9 positively regulates leaf senescence in <i>Arabidopsis</i>.PMC6099856McClung CRKim HVu QTKim HJNam HGJung SHong SfalseCircadian control of <i>ORE1</i> by PRR9 positively regulates leaf senescence in <i>Arabidopsis</i>.The circadian clock coordinates the daily cyclic rhythm of numerous biological processes by regulating a large portion of the transcriptome. In animals, the circadian clock is involved in aging and senescence, and circadian disruption by mutations in clock genes frequently accelerates aging. Conversely, aging alters circadian rhythmicity, which causes age-associated physiological alterations. However, interactions between the circadian clock and aging have been rarely studied in plants. Here, we investigated potential roles for the circadian clock in the regulation of leaf senescence in plants. Members of the evening complex in <i>Arabidopsis</i> circadian clock, EARLY FLOWERING 3 (ELF3), EARLY FLOWERING 4 (ELF4), and LUX ARRHYTHMO (LUX), as well as the morning component PSEUDO-RESPONSE RE2018-01-01T00:00:00Z2018 Aug2025-05-18T12:15:49.546Z2025-05-18T12:15:49.546ZS-EPMC60998563006511610.1073/pnas.1722407115