{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Song J"],"pubmed_abstract":["Osteoarthritis (OA) is the most common degenerative joint disease; however, its etiopathogenesis is not completely understood. Here we show a role for NUDT7 in OA pathogenesis. Knockdown of NUDT7 in normal human chondrocytes results in the disruption of lipid homeostasis. Moreover, Nudt7<sup>-/-</sup> mice display significant accumulation of lipids via peroxisomal dysfunction, upregulation of IL-1β expression, and stimulation of apoptotic death of chondrocytes. Our genome-wide analysis reveals that NUDT7 knockout affects the glycolytic pathway, and we identify Pgam1 as a significantly altered gene. Consistent with the results obtained on the suppression of NUDT7, overexpression of PGAM1 in chondrocytes induces the accumulation of lipids, upregulation of IL-1β expression, and apoptotic cell"],"journal":["Nature communications"],"pagination":["3427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6109082"],"repository":["biostudies-literature"],"pubmed_title":["Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis."],"pmcid":["PMC6109082"],"pubmed_authors":["Jin EJ","Chun CH","Baek IJ","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis.","description":"Osteoarthritis (OA) is the most common degenerative joint disease; however, its etiopathogenesis is not completely understood. Here we show a role for NUDT7 in OA pathogenesis. Knockdown of NUDT7 in normal human chondrocytes results in the disruption of lipid homeostasis. Moreover, Nudt7<sup>-/-</sup> mice display significant accumulation of lipids via peroxisomal dysfunction, upregulation of IL-1β expression, and stimulation of apoptotic death of chondrocytes. Our genome-wide analysis reveals that NUDT7 knockout affects the glycolytic pathway, and we identify Pgam1 as a significantly altered gene. Consistent with the results obtained on the suppression of NUDT7, overexpression of PGAM1 in chondrocytes induces the accumulation of lipids, upregulation of IL-1β expression, and apoptotic cell","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-05-29T18:59:27.826Z","creation":"2025-05-29T18:59:27.826Z"},"accession":"S-EPMC6109082","cross_references":{"pubmed":["30143643"],"doi":["10.1038/s41467-018-05787-0"]}}