biostudies-literatureGuan WNIGMS NIH HHSNIH HHS3231-3237https://www.ebi.ac.uk/biostudies/studies/S-EPMC6112771biostudies-literatureUnknown50(16)Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via these benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings via C-N bond functionalization. This method boasts mild reaction conditions and excellent tolerance for heteroaryl substituents and a range of functional groups.SynthesisVinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts.PMC6112771P30 GM110758P20 GM104316R01 GM111820P20 GM103541S10 OD016267Liao JGuan WWatson MPfalseVinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts.Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via these benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings via C-N bond functionalization. This method boasts mild reaction conditions and excellent tolerance for heteroaryl substituents and a range of functional groups.2018-01-01T00:00:00Z2018 Aug2024-02-16T02:56:20.341Z2019-08-07T07:02:26ZS-EPMC61127713017435310.1055/s-0037-1610084