biostudies-literatureLiu DAustralian-China Collaborative GrantNational Natural Science Foundation of China235https://www.ebi.ac.uk/biostudies/studies/S-EPMC6114873biostudies-literatureUnknown16(1)<h4>Background</h4>Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension.<h4>Methods</h4>Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20-68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography.<h4>Results</h4>Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P < 0.05/57). The canonical correlation aJournal of translational medicineThe changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia.PMC6114873NSFC 815611280208167324781773527NH&amp;MRC-APP11127678153008781370083Guo XHMeng QChu XWang HZhao ZYSun MGe SQDong JLauc GWang WLiu DSong MSWang YXPeng HLWu LJfalseThe changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia.<h4>Background</h4>Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension.<h4>Methods</h4>Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20-68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography.<h4>Results</h4>Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P < 0.05/57). The canonical correlation a2018-01-01T00:00:00Z2018 Aug2025-06-01T03:28:59.298Z2025-06-01T03:28:59.298ZS-EPMC61148733015787810.1186/s12967-018-1616-2