{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lyu H"],"funding":["National Natural Science Foundation of China"],"pagination":["6390-6394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6115682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(30)"],"pubmed_abstract":["A one-pot strategy for efficient and facile synthesis of C,B-substituted carborane-fused N-polyheterocycles is reported. A rhodium catalyzed cascade cyclization of carboranyl N-arylimines with vinyl ketones enables the effective construction of three new B-C and C-C bonds in one reaction. Both carboranyl B-H and aryl C-H bonds are sequentially activated, leading to a series of previously unavailable C,B-substituted carborane-fused cyclopenta[<i>b</i>]quinoline derivatives, for potential applications in pharmaceuticals and materials, in a step-economical manner. The successful isolation and structural identification of a key intermediate provide solid evidence for the reaction mechanism, involving a tandem sequence of regioselective B-H activation, alkene insertion, nucleophilic cyclization"],"journal":["Chemical science"],"pubmed_title":["Rhodium catalyzed cascade cyclization featuring B-H and C-H activation: one-step construction of carborane-fused N-polyheterocycles."],"pmcid":["PMC6115682"],"funding_grant_id":["N_CUHK442/14"],"pubmed_authors":["Lyu H","Xie Z","Quan Y"],"additional_accession":[]},"is_claimable":false,"name":"Rhodium catalyzed cascade cyclization featuring B-H and C-H activation: one-step construction of carborane-fused N-polyheterocycles.","description":"A one-pot strategy for efficient and facile synthesis of C,B-substituted carborane-fused N-polyheterocycles is reported. A rhodium catalyzed cascade cyclization of carboranyl N-arylimines with vinyl ketones enables the effective construction of three new B-C and C-C bonds in one reaction. Both carboranyl B-H and aryl C-H bonds are sequentially activated, leading to a series of previously unavailable C,B-substituted carborane-fused cyclopenta[<i>b</i>]quinoline derivatives, for potential applications in pharmaceuticals and materials, in a step-economical manner. The successful isolation and structural identification of a key intermediate provide solid evidence for the reaction mechanism, involving a tandem sequence of regioselective B-H activation, alkene insertion, nucleophilic cyclization","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-22T12:52:13.406Z","creation":"2019-03-27T00:01:47Z"},"accession":"S-EPMC6115682","cross_references":{"pubmed":["30310567"],"doi":["10.1039/c8sc01568f"]}}