biostudies-literatureUnknown19(8)Moretti RIt is widely known that vitamin D receptors have been found in neurons and glial cells, and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]). Based on these assumptions, we have written this review to summarize the potential role of vitamin D in neurological pathologies. This work could be titanic anInternational journal of molecular sciencesE2245https://www.ebi.ac.uk/biostudies/studies/S-EPMC6121649biostudies-literatureVitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact.PMC6121649Moretti RCaruso PMorelli MEfalseVitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact.It is widely known that vitamin D receptors have been found in neurons and glial cells, and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]). Based on these assumptions, we have written this review to summarize the potential role of vitamin D in neurological pathologies. This work could be titanic an2018-01-01T00:00:00Z2018 Jul2025-04-22T18:35:31.363Z2019-03-26T23:54:53ZS-EPMC61216493006523710.3390/ijms19082245