{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rafaluk-Mohr C"],"funding":["Leverhulme Trust","Oxford University Press","Natural Environment Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["246-256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6121859"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(3)"],"pubmed_abstract":["Species interactions can shift along the parasitism-mutualism continuum. However, the consequences of these transitions for coevolutionary interactions remain unclear. We experimentally coevolved a novel species interaction between <i>Caenorhabditis elegans</i> hosts and a mildly parasitic bacterium, <i>Enterococcus faecalis</i>, with host-protective properties against virulent <i>Staphylococcus aureus</i>. Coinfections drove the evolutionary transition of the <i>C. elegans-E. faecalis</i> relationship toward a reciprocally beneficial interaction. As <i>E. faecalis</i> evolved to protect nematodes against <i>S. aureus</i> infection, hosts adapted by accommodating greater numbers of protective bacteria. The mutualism was strongest in pairings of contemporary coevolved populations. To genera"],"journal":["Evolution letters"],"pubmed_title":["Mutual fitness benefits arise during coevolution in a nematode-defensive microbe model."],"pmcid":["PMC6121859"],"funding_grant_id":["RPG-2015-165","BB/M011224/1","NE/N014979/1"],"pubmed_authors":["Ashby B","Dahan DA","King KC","Rafaluk-Mohr C"],"additional_accession":[]},"is_claimable":false,"name":"Mutual fitness benefits arise during coevolution in a nematode-defensive microbe model.","description":"Species interactions can shift along the parasitism-mutualism continuum. However, the consequences of these transitions for coevolutionary interactions remain unclear. We experimentally coevolved a novel species interaction between <i>Caenorhabditis elegans</i> hosts and a mildly parasitic bacterium, <i>Enterococcus faecalis</i>, with host-protective properties against virulent <i>Staphylococcus aureus</i>. Coinfections drove the evolutionary transition of the <i>C. elegans-E. faecalis</i> relationship toward a reciprocally beneficial interaction. As <i>E. faecalis</i> evolved to protect nematodes against <i>S. aureus</i> infection, hosts adapted by accommodating greater numbers of protective bacteria. The mutualism was strongest in pairings of contemporary coevolved populations. To genera","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-19T16:22:07.222Z","creation":"2019-03-26T23:58:14Z"},"accession":"S-EPMC6121859","cross_references":{"pubmed":["30283680"],"doi":["10.1002/evl3.58"]}}