biostudies-literatureZhang Zhe Major Program of the National Natural Science Foundation of ChinaE1648https://www.ebi.ac.uk/biostudies/studies/S-EPMC6122030biostudies-literatureUnknown15(8)The present study aims to evaluate the potential of transcriptomic profiles in evaluating the impacts of complex mixtures of pollutants at environmentally relevant concentrations on aquatic vertebrates. The changes in gene expression were determined using microarray in the liver of male zebrafish (<i>Danio rerio</i>) exposed to surface water collected from selected locations on the Hun River, China. The numbers of differentially expressed genes (DEGs) in each treatment ranged from 728 to 3292, which were positively correlated with chemical oxygen demand (COD). Predominant transcriptomic responses included peroxisome proliferator-activated receptors (PPAR) signaling and steroid biosynthesis. Key pathways in immune system were also affected. Notably, two human diseases related pathways, insuInternational journal of environmental research and public healthTranscriptomic Profiles in Zebrafish Liver Permit the Discrimination of Surface Water with Pollution Gradient and Different Discharges.PMC61220302016YFC0401108B13012DUT16LK1721590813Zeng PZhang ZHe MLiu RQu YZhou YQuan XLiu WfalseTranscriptomic Profiles in Zebrafish Liver Permit the Discrimination of Surface Water with Pollution Gradient and Different Discharges.The present study aims to evaluate the potential of transcriptomic profiles in evaluating the impacts of complex mixtures of pollutants at environmentally relevant concentrations on aquatic vertebrates. The changes in gene expression were determined using microarray in the liver of male zebrafish (<i>Danio rerio</i>) exposed to surface water collected from selected locations on the Hun River, China. The numbers of differentially expressed genes (DEGs) in each treatment ranged from 728 to 3292, which were positively correlated with chemical oxygen demand (COD). Predominant transcriptomic responses included peroxisome proliferator-activated receptors (PPAR) signaling and steroid biosynthesis. Key pathways in immune system were also affected. Notably, two human diseases related pathways, insu2018-01-01T00:00:00Z2018 Aug2026-05-05T02:29:25.258Z2019-03-26T23:54:54ZS-EPMC61220303008149510.3390/ijerph15081648