{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gyori D"],"funding":["Cancer Research UK","Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["120631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6124419"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(11)"],"pubmed_abstract":["Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we show that genetic ablation of CSF1 in colorectal cancer cells reduces the influx of immunosuppressive CSF1R+ TAMs within tumors. This reduction in CSF1-dependent TAMs resulted in increased CD8+ T cell attack on tumors, but its effect on tumor growth was limited by a compensatory increase in Foxp3+ Treg cells. Similarly, disruption of Treg cell activity through their experimental ablation produced moderate effects on tumor growth and was associated with elevated numbers of CSF1R+ TAMs. Importantly, codepletion of CSF1R+ TAMs and Foxp3+ Treg"],"journal":["JCI insight"],"pubmed_title":["Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy."],"pmcid":["PMC6124419"],"funding_grant_id":["-C0428","095198/Z/10/Z","BBS/E/B/000 -C0407,-C0409,-C0427","BB/N007794/1","BB/J004456/1","C52623/A22597","1947452","22597","BB/E009867/1","105663/Z/14/Z"],"pubmed_authors":["Spensberger D","Shuttleworth SJ","Okkenhaug K","Grant FM","Roychoudhuri R","Lim EL","Stephens LR","Gyori D","Hawkins PT"],"additional_accession":[]},"is_claimable":false,"name":"Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.","description":"Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we show that genetic ablation of CSF1 in colorectal cancer cells reduces the influx of immunosuppressive CSF1R+ TAMs within tumors. This reduction in CSF1-dependent TAMs resulted in increased CD8+ T cell attack on tumors, but its effect on tumor growth was limited by a compensatory increase in Foxp3+ Treg cells. Similarly, disruption of Treg cell activity through their experimental ablation produced moderate effects on tumor growth and was associated with elevated numbers of CSF1R+ TAMs. Importantly, codepletion of CSF1R+ TAMs and Foxp3+ Treg","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2025-04-19T10:56:10.964Z","creation":"2019-03-26T23:54:58Z"},"accession":"S-EPMC6124419","cross_references":{"pubmed":["29875321"],"doi":["10.1172/jci.insight.120631"]}}