{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(3)"],"submitter":["Frase L"],"pubmed_abstract":["<h4>Objective</h4>The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans.<h4>Methods</h4>Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed.<h4>Results</h4>A repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonst"],"journal":["Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology"],"pagination":["253-261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6124878"],"repository":["biostudies-literature"],"pubmed_title":["Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants."],"pmcid":["PMC6124878"],"pubmed_authors":["Riemann D","Fiebich BL","Frase L","Doerr JP","Rechenbach M","Nissen C","Voderholzer U","Feige B"],"additional_accession":[]},"is_claimable":false,"name":"Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants.","description":"<h4>Objective</h4>The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans.<h4>Methods</h4>Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed.<h4>Results</h4>A repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonst","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2025-04-04T22:01:08.662Z","creation":"2019-03-26T23:55:10Z"},"accession":"S-EPMC6124878","cross_references":{"pubmed":["30121974"],"doi":["10.9758/cpn.2018.16.3.253"]}}