{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Watanabe M"],"funding":["Grants-In-Aid for Scientific Research","the Environmental Restoration and Conservation Agency"],"pagination":["169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6126416"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration.<h4>Methods</h4>This prospective observational study evaluated the serum sST2 levels of 104 asthmatic patients who were treated by a lung disease specialist with follow-ups for 3 months.<h4>Results</h4>High serum sST2 levels (> 18 ng/ml) predicted severe asthma exacerbation within 3 months. Serum sST2 levels correlated positively with asthma severity (treatment step), airway H<sub>2</sub>O<sub>2</sub> levels, and serum IL-8 levels. High serum sST2 levels and blood neutrophilia (> 6000 /μl) were "],"journal":["Respiratory research"],"pubmed_title":["Serum sST2 levels predict severe exacerbation of asthma."],"pmcid":["PMC6126416"],"funding_grant_id":["KAKENHI; No. 15K09189"],"pubmed_authors":["Sada M","Yokoyama T","Ogawa Y","Tamura M","Takizawa H","Watanabe M","Honda K","Ishii H","Nakamoto K","Kurai D","Inui T","Saraya T"],"additional_accession":[]},"is_claimable":false,"name":"Serum sST2 levels predict severe exacerbation of asthma.","description":"<h4>Background</h4>Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration.<h4>Methods</h4>This prospective observational study evaluated the serum sST2 levels of 104 asthmatic patients who were treated by a lung disease specialist with follow-ups for 3 months.<h4>Results</h4>High serum sST2 levels (> 18 ng/ml) predicted severe asthma exacerbation within 3 months. Serum sST2 levels correlated positively with asthma severity (treatment step), airway H<sub>2</sub>O<sub>2</sub> levels, and serum IL-8 levels. High serum sST2 levels and blood neutrophilia (> 6000 /μl) were ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-21T17:41:54.746Z","creation":"2019-03-26T23:55:13Z"},"accession":"S-EPMC6126416","cross_references":{"pubmed":["30176857"],"doi":["10.1186/s12931-018-0872-2"]}}