biostudies-literatureWatanabe MGrants-In-Aid for Scientific Researchthe Environmental Restoration and Conservation Agency169https://www.ebi.ac.uk/biostudies/studies/S-EPMC6126416biostudies-literatureUnknown19(1)<h4>Background</h4>Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration.<h4>Methods</h4>This prospective observational study evaluated the serum sST2 levels of 104 asthmatic patients who were treated by a lung disease specialist with follow-ups for 3 months.<h4>Results</h4>High serum sST2 levels (> 18 ng/ml) predicted severe asthma exacerbation within 3 months. Serum sST2 levels correlated positively with asthma severity (treatment step), airway H₂O₂ levels, and serum IL-8 levels. High serum sST2 levels and blood neutrophilia (> 6000 /μl) were Respiratory researchSerum sST2 levels predict severe exacerbation of asthma.PMC6126416KAKENHI; No. 15K09189Sada MYokoyama TOgawa YTamura MTakizawa HWatanabe MHonda KIshii HNakamoto KKurai DInui TSaraya TfalseSerum sST2 levels predict severe exacerbation of asthma.<h4>Background</h4>Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration.<h4>Methods</h4>This prospective observational study evaluated the serum sST2 levels of 104 asthmatic patients who were treated by a lung disease specialist with follow-ups for 3 months.<h4>Results</h4>High serum sST2 levels (> 18 ng/ml) predicted severe asthma exacerbation within 3 months. Serum sST2 levels correlated positively with asthma severity (treatment step), airway H₂O₂ levels, and serum IL-8 levels. High serum sST2 levels and blood neutrophilia (> 6000 /μl) were 2018-01-01T00:00:00Z2018 Sep2025-04-21T17:41:54.746Z2019-03-26T23:55:13ZS-EPMC61264163017685710.1186/s12931-018-0872-2