{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harris S"],"funding":["Department for Environment, Food and Rural Affairs","Biotechnology and Biological Sciences Research Council"],"pagination":["2026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6128206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Bacterial surface polysaccharides play significant roles in fitness and virulence. In Gram-negative bacteria such as <i>Escherichia coli</i>, major surface polysaccharides are lipopolysaccharide (LPS) and capsule, representing O- and K-antigens, respectively. There are multiple combinations of O:K types, many of which are well-characterized and can be related to ecotype or pathotype. In this investigation, we have identified a novel O:K permutation resulting through a process of major genome reorganization in a clade of <i>E. coli</i>. A multidrug-resistant, extended-spectrum β-lactamase (ESBL)-producing strain - <i>E. coli</i> 26561 - represented a prototype of strains combining a locus variant of O89 and group 1 capsular polysaccharide. Specifically, the variant O89 locus in this strain "],"journal":["Frontiers in microbiology"],"pubmed_title":["Variant O89 O-Antigen of <i>E. coli</i> Is Associated With Group 1 Capsule Loci and Multidrug Resistance."],"pmcid":["PMC6128206"],"funding_grant_id":["OD1718"],"pubmed_authors":["Dobrindt U","Goldstone RJ","Harris S","Rao FV","Madec JY","Valat C","Foster G","Qi R","Smith DGE","Piotrowska MJ"],"additional_accession":[]},"is_claimable":false,"name":"Variant O89 O-Antigen of <i>E. coli</i> Is Associated With Group 1 Capsule Loci and Multidrug Resistance.","description":"Bacterial surface polysaccharides play significant roles in fitness and virulence. In Gram-negative bacteria such as <i>Escherichia coli</i>, major surface polysaccharides are lipopolysaccharide (LPS) and capsule, representing O- and K-antigens, respectively. There are multiple combinations of O:K types, many of which are well-characterized and can be related to ecotype or pathotype. In this investigation, we have identified a novel O:K permutation resulting through a process of major genome reorganization in a clade of <i>E. coli</i>. A multidrug-resistant, extended-spectrum β-lactamase (ESBL)-producing strain - <i>E. coli</i> 26561 - represented a prototype of strains combining a locus variant of O89 and group 1 capsular polysaccharide. Specifically, the variant O89 locus in this strain ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-05-04T20:05:01.112Z","creation":"2019-03-26T23:56:34Z"},"accession":"S-EPMC6128206","cross_references":{"pubmed":["30233517"],"doi":["10.3389/fmicb.2018.02026"]}}