{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Min YL"],"funding":["HHS | National Institutes of Health","American Heart Association","Fondation Leducq","NHLBI NIH HHS","Welch Foundation","NIAMS NIH HHS","Cancer Prevention and Research Institute of Texas","NIH HHS"],"pagination":["E8430-E8439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6130356"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(36)"],"pubmed_abstract":["Twist transcription factors function as ancestral regulators of mesodermal cell fates in organisms ranging from <i>Drosophila</i> to mammals. Through lineage tracing of Twist2 (Tw2)-expressing cells with tamoxifen-inducible Tw2-CreERT2 and tdTomato (tdTO) reporter mice, we discovered a unique cell population that progressively contributes to cardiomyocytes (CMs), endothelial cells, and fibroblasts in the adult heart. Clonal analysis confirmed the ability of Tw2-derived tdTO<sup>+</sup> (Tw2-tdTO<sup>+</sup>) cells to form CMs in vitro. Within the adult heart, Tw2-tdTO<sup>+</sup> CMs accounted for ∼13% of total CMs, the majority of which resulted from fusion of Tw2-tdTO<sup>+</sup> cells with existing CMs. Tw2-tdTO<sup>+</sup> cells also contribute to cardiac remodeling after injury. We co"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Identification of a multipotent Twist2-expressing cell population in the adult heart."],"pmcid":["PMC6130356"],"funding_grant_id":["1-0025","R01 AR067294","R01 AR071980","RP150596","13BGIA17150004","R01 HL130253","HL-130253","HL-138426 and AR-071980","S10 OD018005","R01 HL138426","AR-067294","Transatlantic Networks of Excellence in Cardiovascular Research"],"pubmed_authors":["Bassel-Duby R","Cui M","Liu N","Malladi VS","Bezprozvannaya S","Jaichander P","Sanchez-Ortiz E","Wang Z","Olson EN","Min YL"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a multipotent Twist2-expressing cell population in the adult heart.","description":"Twist transcription factors function as ancestral regulators of mesodermal cell fates in organisms ranging from <i>Drosophila</i> to mammals. Through lineage tracing of Twist2 (Tw2)-expressing cells with tamoxifen-inducible Tw2-CreERT2 and tdTomato (tdTO) reporter mice, we discovered a unique cell population that progressively contributes to cardiomyocytes (CMs), endothelial cells, and fibroblasts in the adult heart. Clonal analysis confirmed the ability of Tw2-derived tdTO<sup>+</sup> (Tw2-tdTO<sup>+</sup>) cells to form CMs in vitro. Within the adult heart, Tw2-tdTO<sup>+</sup> CMs accounted for ∼13% of total CMs, the majority of which resulted from fusion of Tw2-tdTO<sup>+</sup> cells with existing CMs. Tw2-tdTO<sup>+</sup> cells also contribute to cardiac remodeling after injury. We co","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2026-05-03T22:28:31.659Z","creation":"2019-08-04T08:13:26Z"},"accession":"S-EPMC6130356","cross_references":{"pubmed":["30127033"],"doi":["10.1073/pnas.1800526115"]}}