biostudies-literatureUnknown8(1)Chung HJThis research was supported by the Research Fund from JINIS Biopharmaceutical Co., Republic of Korea.One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relies on this quality of cancer tissues which with higher temperature becomes more apparent. Despite the obvious necessity to selectively heat the cancer tissue for radiofrequency hyperthermia, a proper thermosensitizer has not been developed until now. Here, we show that transferrin containing ferric ion could be an ideal thermosensitizer for the increased efficiency of radiofrequency hyperthermia. In our result, the ferric ion-enriched cancer tissues dramatically react with 13.5Scientific reports13505https://www.ebi.ac.uk/biostudies/studies/S-EPMC6131143biostudies-literatureTransferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment.PMC6131143Chung HJKim HJHong STLee HKKwon KBfalseTransferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment.One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relies on this quality of cancer tissues which with higher temperature becomes more apparent. Despite the obvious necessity to selectively heat the cancer tissue for radiofrequency hyperthermia, a proper thermosensitizer has not been developed until now. Here, we show that transferrin containing ferric ion could be an ideal thermosensitizer for the increased efficiency of radiofrequency hyperthermia. In our result, the ferric ion-enriched cancer tissues dramatically react with 13.52018-01-01T00:00:00Z2018 Sep2025-05-18T12:20:41.477Z2025-05-18T12:20:41.477ZS-EPMC61311433020200010.1038/s41598-018-31232-9