{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petyuk VA"],"funding":["National Center for Research Resources","NIA NIH HHS","Medical Research Council","NIMH NIH HHS","National Institute for Health Research (NIHR)","NINDS NIH HHS","National Institutes of Health","NIH","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["2721-2739"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6136080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["141(9)"],"pubmed_abstract":["Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream expression of RNA transcripts and how those relationships are changed in late-onset Alzheimer’s disease. We have now examined how proteins are incorporated into networks in two separate series and evaluated our outputs in two different cell lines. Our pipeline included the following steps: (i) predicting expression quantitative trait loci; (ii) determining differential expression; (iii) analysing networks of transcript and peptide relationships; and (iv) validating effects in two separate cell lines. We performed all our analysis in two separate brain series to validate effects. Our two series i"],"journal":["Brain : a journal of neurology"],"pubmed_title":["The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target."],"pmcid":["PMC6136080"],"funding_grant_id":["P30 AG013846","P50 AG005128","P41GM103493","P30 AG053760","P50 AG005146","AG041232","P50 AG005681","P50 AG005144","G0502157","P41 GM103493","P30 AG019610","P41RR018522","G0900652","R01 AG041232","R01 AG034504","P50 AG005134","U01 AG016976","P50 AG005136","NF-SI-0611-10048","P30 AG010161","RF1 AG057457","P50-AG08671","RF1 AG015819","P50 MH060451","G1100540","G0400074","P50 NS039764","R01 AG017917","P50 AG016570"],"pubmed_authors":["Lieberman AP","Beckmann ND","Smith RD","Andreev V","Lovestone S","Myers AJ","Navarro L","Xie F","Ferrer I","Piehowski PD","Wang S","Schadt E","Engel A","De Jager P","Sue LI","Hardy JA","Morris CM","Reiman EM","Henrion MYR","Ervin JF","Chang R","Ramirez-Restrepo M","McKeith IG","Perry RH","Serrano GE","Hulette CM","Clarke J","Petyuk VA","Schneider JA","Bennett DA","Zhu K","Guettoche T","Woltjer RL","Beach TG","Albin RL","Mash DC","Huentelman MJ"],"additional_accession":[]},"is_claimable":false,"name":"The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.","description":"Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream expression of RNA transcripts and how those relationships are changed in late-onset Alzheimer’s disease. We have now examined how proteins are incorporated into networks in two separate series and evaluated our outputs in two different cell lines. Our pipeline included the following steps: (i) predicting expression quantitative trait loci; (ii) determining differential expression; (iii) analysing networks of transcript and peptide relationships; and (iv) validating effects in two separate cell lines. We performed all our analysis in two separate brain series to validate effects. Our two series i","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-18T13:29:14.2Z","creation":"2019-03-26T23:56:53Z"},"accession":"S-EPMC6136080","cross_references":{"pubmed":["30137212"],"doi":["10.1093/brain/awy215"]}}