biostudies-literatureUnknown7(8)Buglioni SWhether PD-L1 expression is associated with survival outcomes in gastric cancer (GC) is controversial. The inhibition of the PD-1/PD-L1 pathway is effective against genomically unstable tumors. Hypothesizing that also the clinical significance of PD-L1 might be dependent on the activation of molecular circuits ensuring genomic stability, we evaluated PD-L1 expression in tissue samples from 72 advanced GC patients treated with first-line chemotherapy. Samples were already characterized for DNA damage repair (DDR) component expression (pATM, pChk1, pWee1, γ-H2AX and pRPA2) along with mutations in DDR-linked genes (<i>TP53</i> and <i>ARID1A</i>). Overall, PD-L1 expression was not associated with progression-free survival (PFS) and overall survival (OS), independently on whether we considered Oncoimmunologye1457602https://www.ebi.ac.uk/biostudies/studies/S-EPMC6136851biostudies-literatureThe clinical significance of PD-L1 in advanced gastric cancer is dependent on <i>ARID1A</i> mutations and ATM expression.PMC6136851Buglioni SDiodoro MGCiliberto GFanciulli MBarba MPescarmona ESperati FMaugeri-Sacca MGoeman FVitale IDe Maria RDe Nicola FTerrenato IPizzuti LDi Lauro LCasini BSergi DMelucci EAmoreo CAPallocca MMazzotta MGallo EVici PfalseThe clinical significance of PD-L1 in advanced gastric cancer is dependent on <i>ARID1A</i> mutations and ATM expression.Whether PD-L1 expression is associated with survival outcomes in gastric cancer (GC) is controversial. The inhibition of the PD-1/PD-L1 pathway is effective against genomically unstable tumors. Hypothesizing that also the clinical significance of PD-L1 might be dependent on the activation of molecular circuits ensuring genomic stability, we evaluated PD-L1 expression in tissue samples from 72 advanced GC patients treated with first-line chemotherapy. Samples were already characterized for DNA damage repair (DDR) component expression (pATM, pChk1, pWee1, γ-H2AX and pRPA2) along with mutations in DDR-linked genes (<i>TP53</i> and <i>ARID1A</i>). Overall, PD-L1 expression was not associated with progression-free survival (PFS) and overall survival (OS), independently on whether we considered 2018-01-01T00:00:00Z20182025-04-04T10:18:42.366Z2019-06-06T22:45:52ZS-EPMC61368513022105310.1080/2162402x.2018.145760210.1080/2162402X.2018.1457602