{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Z"],"funding":["Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation)","NIDCR NIH HHS"],"pagination":["3713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6137151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["The use of natural substance to ward off microbial infections has a long history. However, the large-scale production of natural extracts often reduces antibacterial potency, thus limiting practical applications. Here we present a strategy for converting natural organosulfur compounds into nano-iron sulfides that exhibit enhanced antibacterial activity. We show that compared to garlic-derived organosulfur compounds nano-iron sulfides exhibit an over 500-fold increase in antibacterial efficacy to kill several pathogenic and drug-resistant bacteria. Furthermore, our analysis reveals that hydrogen polysulfanes released from nano-iron sulfides possess potent bactericidal activity and the release of polysulfanes can be accelerated by the enzyme-like activity of nano-iron sulfides. Finally, we demonstrate that topical applications of nano-iron sulfides can effectively disrupt pathogenic biofilms on human teeth and accelerate infected-wound healing. Together, our approach to convert organosulfur compounds into inorganic polysulfides potentially provides an antibacterial alternative to combat bacterial infections."],"journal":["Nature communications"],"pubmed_title":["Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections."],"pmcid":["PMC6137151"],"funding_grant_id":["R01 DE025848","20161333"],"pubmed_authors":["Jiang J","Li D","Gu Y","He J","Koo H","Liu Q","Yan X","Xu J","Qiu Z","Liu Y","Xi J","Huang Y","Fan K","Gao L","Gao X","Shen X","Xu Z","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections.","description":"The use of natural substance to ward off microbial infections has a long history. However, the large-scale production of natural extracts often reduces antibacterial potency, thus limiting practical applications. Here we present a strategy for converting natural organosulfur compounds into nano-iron sulfides that exhibit enhanced antibacterial activity. We show that compared to garlic-derived organosulfur compounds nano-iron sulfides exhibit an over 500-fold increase in antibacterial efficacy to kill several pathogenic and drug-resistant bacteria. Furthermore, our analysis reveals that hydrogen polysulfanes released from nano-iron sulfides possess potent bactericidal activity and the release of polysulfanes can be accelerated by the enzyme-like activity of nano-iron sulfides. Finally, we demonstrate that topical applications of nano-iron sulfides can effectively disrupt pathogenic biofilms on human teeth and accelerate infected-wound healing. Together, our approach to convert organosulfur compounds into inorganic polysulfides potentially provides an antibacterial alternative to combat bacterial infections.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2021-02-20T13:14:16Z","creation":"2019-03-26T23:56:14Z"},"accession":"S-EPMC6137151","cross_references":{"pubmed":["30213949"],"doi":["10.1038/s41467-018-06164-7"]}}