{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(5)"],"submitter":["Chen X"],"pubmed_abstract":["Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease (CKD) patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs. Participants with SSN intervention took 5 g SSN granule three times daily for 12 weeks, while the baseline medications and dialysis prescriptions remained during the study in all patients. The serum concentrations of indoxyl sul"],"journal":["Bioscience reports"],"pagination":["BSR20171694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6137246"],"repository":["biostudies-literature"],"pubmed_title":["Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis."],"pmcid":["PMC6137246"],"pubmed_authors":["Pan X","Ruan M","Xing X","Mei C","Chen X","Chen S","Gao S","Xu J","Mao Z"],"additional_accession":[]},"is_claimable":false,"name":"Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis.","description":"Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease (CKD) patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs. Participants with SSN intervention took 5 g SSN granule three times daily for 12 weeks, while the baseline medications and dialysis prescriptions remained during the study in all patients. The serum concentrations of indoxyl sul","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2026-06-14T06:09:51.713Z","creation":"2026-06-14T03:16:04.282Z"},"accession":"S-EPMC6137246","cross_references":{"pubmed":["29921575"],"doi":["10.1042/BSR20171694"]}}