biostudies-literatureOelsner ECNCATS NIH HHSNCRR NIH HHSNIEHS NIH HHSNHLBI NIH HHS718-727https://www.ebi.ac.uk/biostudies/studies/S-EPMC6137677biostudies-literatureUnknown15(6)<h4>Rationale</h4>Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in chronic obstructive pulmonary disease (COPD), as well as with symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined.<h4>Objectives</h4>To examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease.<h4>Methods</h4>The Multi-Ethnic Study of Atherosclerosis recruited participants ages 45-84 years without cardiovascular disease in 2000-2002; we excluded participants with prevalent chronic lower respiratory disease (CLRD). Spirometry was measured in 2004-2006 and 2010-2012. CLRD hospitalizations and deaths were classified by validated criteria through 2014. The average wall thickness for a hypothetical airway of 10-mm lumen perimeter on CT (Pi10) was calculated using measures of airway wall thickness and lumen diameter. Models were adjusted for age, sex, principal components of ancestry, body mass index, smoking, pack-years, scanner, percent emphysema, genetic risk score, and initial forced expiratory volume in 1 second (FEV₁) percent predicted.<h4>Results</h4>Greater Pi10 was associated with 9% faster FEV₁ decline (95% confidence interval [CI], 2 to 15%; P = 0.012) and increased incident COPD (odds ratio, 2.22; 95% CI, 1.43-3.45; P = 0.0004) per standard deviation among 1,830 participants. Over 78,147 person-years, higher Pi10 was associated with a 57% higher risk of first CLRD hospitalization or mortality (P = 0.0496) per standard deviation. Of Pi10's component measures, both greater airway wall thickness and narrower lumen predicted incident COPD and CLRD clinical events.<h4>Conclusions</h4>In adults without CLRD, large airway dimensions on CT were prospectively associated with accelerated lung function decline and increased risks of COPD and CLRD hospitalization and mortality.Annals of the American Thoracic SocietyPrognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study.PMC6137677UL1 TR000040R21 HL129924R01 HL077612P30 ES005605N01HC95160N01HC95161R01 HL093081N01HC95162N01HC95163N01HC95164N01HC95165N01HC95166R01 HL130506R01 HL112986N01HC95167N01HC95168R01 HL075476N01HC95169N01HC95159K23 HL130627UL1 RR025005P30 ES009089Smith BMSchwartz JERotter JIFolsom ARKaufman JDBarr RGDonohue KMOelsner ECBurke GLWatson KKalhan RNguyen JNHoffman EAMichos EDManichaikul AWJacobs DRfalsePrognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study.<h4>Rationale</h4>Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in chronic obstructive pulmonary disease (COPD), as well as with symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined.<h4>Objectives</h4>To examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease.<h4>Methods</h4>The Multi-Ethnic Study of Atherosclerosis recruited participants ages 45-84 years without cardiovascular disease in 2000-2002; we excluded participants with prevalent chronic lower respiratory disease (CLRD). Spirometry was measured in 2004-2006 and 2010-2012. CLRD hospitalizations and deaths were classified by validated criteria through 2014. The average wall thickness for a hypothetical airway of 10-mm lumen perimeter on CT (Pi10) was calculated using measures of airway wall thickness and lumen diameter. Models were adjusted for age, sex, principal components of ancestry, body mass index, smoking, pack-years, scanner, percent emphysema, genetic risk score, and initial forced expiratory volume in 1 second (FEV₁) percent predicted.<h4>Results</h4>Greater Pi10 was associated with 9% faster FEV₁ decline (95% confidence interval [CI], 2 to 15%; P = 0.012) and increased incident COPD (odds ratio, 2.22; 95% CI, 1.43-3.45; P = 0.0004) per standard deviation among 1,830 participants. Over 78,147 person-years, higher Pi10 was associated with a 57% higher risk of first CLRD hospitalization or mortality (P = 0.0496) per standard deviation. Of Pi10's component measures, both greater airway wall thickness and narrower lumen predicted incident COPD and CLRD clinical events.<h4>Conclusions</h4>In adults without CLRD, large airway dimensions on CT were prospectively associated with accelerated lung function decline and increased risks of COPD and CLRD hospitalization and mortality.2018-01-01T00:00:00Z2018 Jun2022-07-23T16:04:08.268Z2019-08-21T07:00:38ZS-EPMC61376772952938210.1513/annalsats.201710-820oc10.1513/AnnalsATS.201710-820OC