biostudies-literatureChen KDChang Gung Memorial Hospital163-168https://www.ebi.ac.uk/biostudies/studies/S-EPMC6138774biostudies-literatureUnknown41(3)The physiological role of autophagy in the catabolic process of the body involves protein synthesis and degradation in homeostasis under normal and stressed conditions. In hepatocellular carcinoma (HCC), the role of tumor microenvironment (TME) has been concerned as the main issue in fighting against this deadly malignancy. During the last decade, the crosstalk between tumor cells and their TME in HCC extensively accumulated. However, a deeper knowledge for the actual function of autophagy in this interconnection which involved in supporting tumor development, progression and chemoresistance in HCC is needed but still largely unknown. Recent studies have shown that coagulants tissue factor (TF) and factor VII (FVII) has a pathological role in promoting tumor growth by activating protease-aBiomedical journalTumor microenvironment mediated by suppression of autophagic flux drives liver malignancy.PMC6138774CMRPG8F0621CMRPG8E1651CMRPG8C1151CMRPG8D1033CMRPG8D1022CMRPG8D1023CMRPG8D1001CMRPG8D0561CMRPG8D1032CMRPG8D0751CMRPG8F0661CMRPG8F0662CMRPG8A1203Chen KDTsai MCLin CCHuang KTChiu KWfalseTumor microenvironment mediated by suppression of autophagic flux drives liver malignancy.The physiological role of autophagy in the catabolic process of the body involves protein synthesis and degradation in homeostasis under normal and stressed conditions. In hepatocellular carcinoma (HCC), the role of tumor microenvironment (TME) has been concerned as the main issue in fighting against this deadly malignancy. During the last decade, the crosstalk between tumor cells and their TME in HCC extensively accumulated. However, a deeper knowledge for the actual function of autophagy in this interconnection which involved in supporting tumor development, progression and chemoresistance in HCC is needed but still largely unknown. Recent studies have shown that coagulants tissue factor (TF) and factor VII (FVII) has a pathological role in promoting tumor growth by activating protease-a2018-01-01T00:00:00Z2018 Jun2025-04-22T06:40:19.213Z2019-03-26T23:57:15ZS-EPMC61387743008065610.1016/j.bj.2018.03.002