biostudies-literatureGuo RNational Key R&amp;D Program of China64https://www.ebi.ac.uk/biostudies/studies/S-EPMC6139904biostudies-literatureUnknown20(1)<h4>Background</h4>This study demonstrates a three-dimensional (3D) free-breathing native myocardial T₁ mapping sequence at 3 T.<h4>Methods</h4>The proposed sequence acquires three differently T₁-weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration. The proposed sequence was validated through simulation, phantom experiments and in vivo experiments in 12 healthy adult subjects.<h4>Results</h4>In phantoms, good agreement on T₁ measurement was achieved between the proposed sequence and the reference inversion rJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceThree-dimensional free breathing whole heart cardiovascular magnetic resonance T₁ mapping at 3 T.PMC61399042017YFC01087002016YFC0104700Ding HChen ZLuo JHerzka DAGuo RWang YfalseThree-dimensional free breathing whole heart cardiovascular magnetic resonance T₁ mapping at 3 T.<h4>Background</h4>This study demonstrates a three-dimensional (3D) free-breathing native myocardial T₁ mapping sequence at 3 T.<h4>Methods</h4>The proposed sequence acquires three differently T₁-weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration. The proposed sequence was validated through simulation, phantom experiments and in vivo experiments in 12 healthy adult subjects.<h4>Results</h4>In phantoms, good agreement on T₁ measurement was achieved between the proposed sequence and the reference inversion r2018-01-01T00:00:00Z2018 Sep2025-04-04T09:26:52.823Z2019-03-26T23:56:42ZS-EPMC61399043022025410.1186/s12968-018-0487-2